Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA

Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA

Abstract Background Chronic infection with hepatitis B virus (HBV) is a serious global health problem. Persistence of the virus occurs as a result of stability of the replication intermediate comprising covalently closed circular DNA (cccDNA). Development of drugs that are capable of disabling this...

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Bibliographic Details
Main Authors: Kristie Bloom, Haajira Kaldine, Toni Cathomen, Claudio Mussolino, Abdullah Ely, Patrick Arbuthnot
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Infectious Diseases
Subjects:
HBV
Transcriptional repressor
TALE
KRAB
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s12879-019-4436-y

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http://link.springer.com/article/10.1186/s12879-019-4436-y

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