Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research

Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research

Abstract Background Genetic engineering technology such as clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system provides a powerful tool for developing disease models and determining gene functions. Recent interests in canine cancer models have highlighted the necessity of...

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Bibliographic Details
Main Authors: Kiyoung Eun, Min Gi Park, Yeon Woo Jeong, Yeon Ik Jeong, Sang-Hwan Hyun, Woo Suk Hwang, Sung-Hak Kim, Hyunggee Kim
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Biotechnology
Subjects:
CRISPR/Cas9
Dog
TP53
Knockout
Cancer
Online Access:http://link.springer.com/article/10.1186/s12896-018-0491-5

Internet

http://link.springer.com/article/10.1186/s12896-018-0491-5

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