Protein Misdirection Inside and Outside Motor Neurons in Amyotrophic Lateral Sclerosis (ALS): A Possible Clue for Therapeutic Strategies

Protein Misdirection Inside and Outside Motor Neurons in Amyotrophic Lateral Sclerosis (ALS): A Possible Clue for Therapeutic Strategies

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive muscle wasting and weakness with no effective cure. Emerging evidence supports the notion that the abnormal conformations of ALS-linked proteins play a central role in triggering the motor neu...

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Bibliographic Details
Main Authors: Akemi Ido, Makoto Urushitani, Hidenao Fukuyama
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:International Journal of Molecular Sciences
Subjects:
seeding
subcellular localization
SOD1
TDP-43
non-cell-autonomous motor neuron death
antibody
Online Access:http://www.mdpi.com/1422-0067/12/10/6980/

Internet

http://www.mdpi.com/1422-0067/12/10/6980/

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