Generation and characterization of a human iPSC line from an ALS patient carrying the Q66K-MATR3 mutation

Generation and characterization of a human iPSC line from an ALS patient carrying the Q66K-MATR3 mutation

Fibroblasts isolated from an Amyotrophic Lateral Sclerosis (ALS)-patient carrying a mutation in Matrin-3 (p.Q66K -MATR3) gene were reprogrammed to the pluripotency stage by using non-integrating episomal plasmids. We generated the Q66K#44DRM induced pluripotent stem cell (iPSC) line that showed regu...

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Bibliographic Details
Main Authors: Daniele Pollini, Rosa Loffredo, Marina Cardano, Luciano Conti, Serena Lattante, Angelantonio Notarangelo, Mario Sabatelli, Alessandro Provenzani
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118302538

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http://www.sciencedirect.com/science/article/pii/S1873506118302538

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