Autophagy facilitates type I collagen synthesis in periodontal ligament cells

Abstract Autophagy is a lysosomal protein degradation system in which the cell self-digests its intracellular protein components and organelles. Defects in autophagy contribute to the pathogenesis of age-related chronic diseases, such as myocardial infarction and rheumatoid arthritis, through defect...

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Bibliographic Details
Main Authors: Tomomi Nakamura, Motozo Yamashita, Kuniko Ikegami, Mio Suzuki, Manabu Yanagita, Jirouta Kitagaki, Masahiro Kitamura, Shinya Murakami
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80275-4