Up-Regulation of Immune Checkpoints in the Thymus of PRRSV-1-Infected Piglets in a Virulence-Dependent Fashion

Up-Regulation of Immune Checkpoints in the Thymus of PRRSV-1-Infected Piglets in a Virulence-Dependent Fashion

Virulent porcine reproductive and respiratory syndrome virus (PRRSV) strains, such as the Lena strain, have demonstrated a higher thymus tropism than low virulent strains. Virulent PRRSV strains lead to severe thymus atrophy, which could be related to marked immune dysregulation. Impairment of T-cel...

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Bibliographic Details
Main Authors: Inés Ruedas-Torres, Irene M. Rodríguez-Gómez, José María Sánchez-Carvajal, Silvia Guil-Luna, Fernanda Larenas-Muñoz, Francisco J. Pallarés, Librado Carrasco, Jaime Gómez-Laguna
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
immune checkpoints
thymus
immunosuppression
T-cell exhaustion
PRRSV
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.671743/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.671743/full

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