Surface area loss and increased sphericity account for the splenic entrapment of subpopulations of Plasmodium falciparum ring-infected erythrocytes.

Surface area loss and increased sphericity account for the splenic entrapment of subpopulations of Plasmodium falciparum ring-infected erythrocytes.

Ex vivo perfusion of human spleens revealed innate retention of numerous cultured Plasmodium falciparum ring-infected red blood cells (ring-iRBCs). Ring-iRBC retention was confirmed by a microsphiltration device, a microbead-based technology that mimics the mechanical filtering function of the human...

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Main Authors: Innocent Safeukui, Pierre A Buffet, Sylvie Perrot, Alain Sauvanet, Beatrice Aussilhou, Safi Dokmak, Anne Couvelard, Dominique Cazals Hatem, Narla Mohandas, Peter H David, Odile Mercereau-Puijalon, Geneviève Milon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3610737?pdf=render

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http://europepmc.org/articles/PMC3610737?pdf=render

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