C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages

C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages

Gaucher disease (GD) is an autosomal recessive disorder caused by bi-allelic <i>GBA1</i> mutations that reduce the activity of the lysosomal enzyme β-glucocerebrosidase (GCase). GCase catalyzes the conversion of glucosylceramide (GluCer), a ubiquitous glycosphingolipid, to glucose and ce...

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Bibliographic Details
Main Authors: Jacquelyn C. Serfecz, Afsoon Saadin, Clayton P. Santiago, Yuji Zhang, Søren M. Bentzen, Stefanie N. Vogel, Ricardo A. Feldman
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
gaucher disease
induced pluripotent stem cells (iPSC)
macrophages
complement
C5a
inflammation
Online Access:https://www.mdpi.com/1422-0067/22/18/9912

Internet

https://www.mdpi.com/1422-0067/22/18/9912

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