C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages
Gaucher disease (GD) is an autosomal recessive disorder caused by bi-allelic <i>GBA1</i> mutations that reduce the activity of the lysosomal enzyme β-glucocerebrosidase (GCase). GCase catalyzes the conversion of glucosylceramide (GluCer), a ubiquitous glycosphingolipid, to glucose and ce...
Main Authors: | Jacquelyn C. Serfecz, Afsoon Saadin, Clayton P. Santiago, Yuji Zhang, Søren M. Bentzen, Stefanie N. Vogel, Ricardo A. Feldman |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/18/9912 |
Similar Items
-
Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease
by: Manasa P. Srikanth, et al.
Published: (2020-12-01) -
The EBiSC iPSC bank for disease studies
by: Rachel Steeg, et al.
Published: (2020-12-01) -
Human iPSC banking: barriers and opportunities
by: Ching-Ying Huang, et al.
Published: (2019-10-01) -
iPSC Bioprinting: Where are We at?
by: Sara Romanazzo, et al.
Published: (2019-08-01) -
Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives
by: Go Itakura, et al.
Published: (2017-03-01)