What Goes around Comes around-A Comparative Study of the Influence of Chemical Modifications on the Antimicrobial Properties of Small Cyclic Peptides

What Goes around Comes around-A Comparative Study of the Influence of Chemical Modifications on the Antimicrobial Properties of Small Cyclic Peptides

Tryptophan and arginine-rich cyclic hexapeptides of the type cyclo-RRRWFW combine high antibacterial activity with rapid cell killing kinetics, but show low toxicity in human cell lines. The peptides fulfil the structural requirements for membrane interaction such as high amphipathicity and cationic...

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Bibliographic Details
Main Authors: Margitta Dathe, Marina Rautenbach, Igor V. Komarov, Heike Nikolenko, Kathi Scheinpflug
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Pharmaceuticals
Subjects:
cyclic hexapeptides
antimicrobial activity
mode of action
permeabilisation
chemical modification
Online Access:http://www.mdpi.com/1424-8247/6/9/1130

Internet

http://www.mdpi.com/1424-8247/6/9/1130

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