Mechanism underlying defective interferon gamma-induced IDO expression in non-obese diabetic mouse fibroblasts.

Mechanism underlying defective interferon gamma-induced IDO expression in non-obese diabetic mouse fibroblasts.

Indoleamine 2,3-dioxygenase (IDO) can locally suppress T cell-mediated immune responses. It has been shown that defective self-tolerance in early prediabetic female non-obese diabetic (NOD) mice can be attributed to the impaired interferon-gamma (IFN-γ)- induced IDO expression in dendritic cells of...

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Bibliographic Details
Main Authors: Azadeh Hosseini-Tabatabaei, Reza Baradar Jalili, Yunyuan Li, Ruhangiz T Kilani, Alireza Moeen Rezakhanlou, Aziz Ghahary
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360620?pdf=render

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http://europepmc.org/articles/PMC3360620?pdf=render

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