Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: No impact on survival of seizure-generated neurons

Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: No impact on survival of seizure-generated neurons

Partial and generalized status epilepticus (pSE and gSE) trigger the same level of progenitor cell proliferation in adult dentate gyrus, but survival of new neurons is poor after gSE. Here, we show markedly elevated levels of prostaglandin E2 (PGE2) and brain-derived neurotrophic factor (BDNF) in ra...

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Bibliographic Details
Main Authors: Maria Antonietta Ajmone-Cat, Robert E. Iosif, Christine T. Ekdahl, Zaal Kokaia, Luisa Minghetti, Olle Lindvall
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neurobiology of Disease
Subjects:
Prostaglandin E2 (PGE2)
Cyclooxygenase-2 (COX-2)
Brain-derived neurotrophic factor (BDNF)
EP2
EP3
Isoprostanes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000167

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http://www.sciencedirect.com/science/article/pii/S0969996106000167

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