Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.

Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordinator of the cell-autonomous clocks distributed acro...

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Bibliographic Details
Main Authors: Nan Yang, Nicola J Smyllie, Honor Morris, Cátia F Gonçalves, Michal Dudek, Dharshika R J Pathiranage, Johanna E Chesham, Antony Adamson, David G Spiller, Egor Zindy, James Bagnall, Neil Humphreys, Judith Hoyland, Andrew S I Loudon, Michael H Hastings, Qing-Jun Meng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008729

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https://doi.org/10.1371/journal.pgen.1008729

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