Neonatal Mice Lacking Neuronal Nitric Oxide Synthase Are Less Vulnerable to Hypoxic–Ischemic Injury

We hypothesized that elimination of neuronal nitric oxide synthase (nNOS) by targeted disruption of the nNOS gene would result in amelioration of damage seen after hypoxia–ischemia in the developing brain since nitric oxide (NO) has been implicated in glutamate-mediated neurotoxicity after ischemia....

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Bibliographic Details
Main Authors: Donna M. Ferriero, David M. Holtzman, Stephen M. Black, R.Ann Sheldon
Format: Article
Language:English
Published: Elsevier 1996-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996196900066