Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling †

Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-β1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling †

The antifibrotic potential of platelet-rich plasma (PRP) is controversial. This study examined the effects of PRP on in vitro transforming growth factor (TGF)-β1-induced differentiation of fibroblasts into myofibroblasts, the main drivers of fibrosis, and the involvement of vascular endothe...

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Bibliographic Details
Main Authors: Flaminia Chellini, Alessia Tani, Larissa Vallone, Daniele Nosi, Paola Pavan, Franco Bambi, Sandra Zecchi Orlandini, Chiara Sassoli
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cells
Subjects:
myofibroblasts
fibrosis
platelet-rich plasma (PRP)
vascular endothelial growth factor (VEGF)-A
VEGFR-1/flt-1
Notch-1
transforming growth factor (TGF)-β1/Smad3
α-smooth muscle actin
Connexin 43
confocal immunofluorescence
Online Access:http://www.mdpi.com/2073-4409/7/9/142

Internet

http://www.mdpi.com/2073-4409/7/9/142

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