Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer

TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer. Recently, the kinase MKK3 emerged as a potential therapeutic target in different types of solid tumor being linked...

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Bibliographic Details
Main Authors: Lorenzo Stramucci, Angelina Pranteda, Gianluca Bossi
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Cancers
Subjects:
p53
Online Access:http://www.mdpi.com/2072-6694/10/5/131