Long-Term Inhibition of Notch in A-375 Melanoma Cells Enhances Tumor Growth Through the Enhancement of AXIN1, CSNK2A3, and CEBPA2 as Intermediate Genes in Wnt and Notch Pathways

Long-Term Inhibition of Notch in A-375 Melanoma Cells Enhances Tumor Growth Through the Enhancement of AXIN1, CSNK2A3, and CEBPA2 as Intermediate Genes in Wnt and Notch Pathways

Notch suppression by gamma-secretase inhibitors is a valid approach against melanoma. However, most of studies have evaluated the short-term effect of DAPT on tumor cells or even cancer stem cells. In the present study, we surveyed the short-term and long-term effects of DAPT on the stem cell proper...

Full description

Bibliographic Details
Main Authors: Faezeh Keyghobadi, Maryam Mehdipour, Vahab Nekoukar, Javad Firouzi, Abolfazl Kheimeh, Fatemeh Nobakht Lahrood, Vajihe Azimian Zavareh, Masoumeh Azimi, Mahsa Mohammadi, Niloofar Sodeifi, Marzieh Ebrahimi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
DAPT
Notch signaling pathway
melanoma
mathematical model
xenograft model
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00531/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00531/full

Similar Items