Effects of genetic deletion versus pharmacological blockade of the LPA1 receptor on depression-like behaviour and related brain functional activity

Effects of genetic deletion versus pharmacological blockade of the LPA1 receptor on depression-like behaviour and related brain functional activity

Animal models of psychopathology are particularly useful for studying the neurobiology of depression and characterising the subtypes. Recently, our group was the first to identify a possible relationship between the LPA1 receptor and a mixed anxiety-depression phenotype. Specifically, maLPA1-null mi...

Full description

Bibliographic Details
Main Authors: Román Darío Moreno-Fernández, Andrea Nieto-Quero, Francisco Javier Gómez-Salas, Jerold Chun, Guillermo Estivill-Torrús, Fernando Rodríguez de Fonseca, Luis Javier Santín, Margarita Pérez-Martín, Carmen Pedraza
Format: Article
Language:English
Published: The Company of Biologists 2018-09-01
Series:Disease Models & Mechanisms
Subjects:
Animal models
LPA1 receptor
Genetic deletion
Antagonist
Functional brain mapping
Mixed anxiety-depression phenotype
Online Access:http://dmm.biologists.org/content/11/9/dmm035519

Internet

http://dmm.biologists.org/content/11/9/dmm035519

Similar Items