Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice.

Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice.

We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice.We investigated the effects of COX-1 and COX-2 inhibitors in influenza A viral i...

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Bibliographic Details
Main Authors: Michelle A Carey, J Alyce Bradbury, Yvette D Rebolloso, Joan P Graves, Darryl C Zeldin, Dori R Germolec
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2904706?pdf=render

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http://europepmc.org/articles/PMC2904706?pdf=render

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