Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach

Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach

Background: Chemotherapy and targeted agent anti-cancer efficacy is largely dependent on the proliferative state of tumours, as exemplified by agents that target DNA synthesis/replication or mitosis. As a result, cell cycle specificities of a number of cancer drugs are well known. However, they are...

Full description

Bibliographic Details
Main Authors: Timothy I. Johnson, Christopher J. Minteer, Daniel Kottmann, Charles R. Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S. Carnevalli, Yann Wallez, Alan Lau, Frances M. Richards, Duncan I. Jodrell
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:EBioMedicine
Subjects:
Cancer
cell cycle
synchronisation
high throughput screening
combination treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001894

Internet

http://www.sciencedirect.com/science/article/pii/S2352396421001894

Similar Items