The efficacy of cetuximab in a tissue-engineered three-dimensional in vitro model of colorectal cancer

The preclinical development process of chemotherapeutic drugs is often carried out in two-dimensional monolayer cultures. However, a considerable amount of evidence demonstrates that two-dimensional cell culture does not accurately reflect the three-dimensional in vivo tumour microenvironment, speci...

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Bibliographic Details
Main Authors: Tarig Magdeldin, Víctor López-Dávila, Cecile Villemant, Grant Cameron, Rosemary Drake, Umber Cheema, Marilena Loizidou
Format: Article
Language:English
Published: SAGE Publishing 2014-07-01
Series:Journal of Tissue Engineering
Online Access:https://doi.org/10.1177/2041731414544183