Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

Abstract Background Acute liver failure (ALF) is an acute inflammatory liver disease with high mortality. Previous preclinical and clinical trials have confirmed that mesenchymal stem cell (MSC) is a promising therapeutic approach; however, the effect is not satisfied as the underlying molecular mec...

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Bibliographic Details
Main Authors: Jinglin Wang, Yang Liu, Haoran Ding, Xiaolei Shi, Haozhen Ren
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Acute liver failure
MSC
PGE2
mTOR
Macrophages
Online Access:https://doi.org/10.1186/s13287-020-02070-2

Internet

https://doi.org/10.1186/s13287-020-02070-2

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