A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML

A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML

<i>HOXA9</i> and <i>MEIS1</i> are frequently upregulated in acute myeloid leukemia (AML), including those with MLL-rearrangement. Because of their pivotal role in hemostasis, HOXA9 and MEIS1 appear non-druggable. We, thus, interrogated gene expression data of pre-leukemic (ov...

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Bibliographic Details
Main Authors: Jacob Jalil Hassan, Anna Lieske, Nicole Dörpmund, Denise Klatt, Dirk Hoffmann, Marc-Jens Kleppa, Olga S. Kustikova, Maike Stahlhut, Adrian Schwarzer, Axel Schambach, Tobias Maetzig
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukemia
leukemic stem cell
<i>Pla2g4a</i>
<i>Hoxa9</i>
<i>Meis1</i>
shRNA
Online Access:https://www.mdpi.com/1422-0067/22/17/9411

Internet

https://www.mdpi.com/1422-0067/22/17/9411

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