WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms

WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms

Abstract Background Targeting the endocannabinoid system has emerged as an effective strategy for the treatment of inflammatory and neurological diseases. Unlike the inhibition of the principal 2-arachidonyl glycerol (2-AG) hydrolytic enzyme monoacylglycerol lipase (MAGL), which leads to 2-AG overlo...

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Bibliographic Details
Main Authors: Jie Wen, Melissa Jones, Mikiei Tanaka, Prabhuanand Selvaraj, Aviva J. Symes, Brian Cox, Yumin Zhang
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Neuroinflammation
Subjects:
Endocannabinoids
ABHD6
Chronic constriction injury
Neuroinflammation
Cyclooxygenase-2
Prostaglandin E synthase
Online Access:http://link.springer.com/article/10.1186/s12974-017-1045-9

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http://link.springer.com/article/10.1186/s12974-017-1045-9

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