Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes to the skeleton, endocrine system, reproductive orga...

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Bibliographic Details
Main Authors: Laura J. Lambert, Anil K. Challa, Aidi Niu, Lihua Zhou, Janusz Tucholski, Maria S. Johnson, Tim R. Nagy, Alan W. Eberhardt, Patrick N. Estep, Robert A. Kesterson, Jayleen M. Grams
Format: Article
Language:English
Published: The Company of Biologists 2016-10-01
Series:Disease Models & Mechanisms
Subjects:
Osteocalcin
Bone strength
Bone structure
Genetic animal models
Osteocalcin knockout
Online Access:http://dmm.biologists.org/content/9/10/1169

Internet

http://dmm.biologists.org/content/9/10/1169

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