Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:RagB and RagC:RagD heterodimers. Rags control mTORC1 activity by tethering mTOR...

Full description

Bibliographic Details
Main Authors: Anita Parmigiani, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, Andrei V. Budanov
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714008730

Internet

http://www.sciencedirect.com/science/article/pii/S2211124714008730

Similar Items