Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model

Adenoviral TMBIM6 vector attenuates ER-stress-induced apoptosis in a neonatal hypoxic-ischemic rat model

Endoplasmic reticulum (ER) stress is a major pathology encountered after hypoxic-ischemic (HI) injury. Accumulation of unfolded proteins triggers the unfolded protein response (UPR), resulting in the activation of pro-apoptotic cascades that lead to cell death. Here, we identified Bax inhibitor 1 (B...

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Bibliographic Details
Main Authors: Desislava Doycheva, Ningbo Xu, Harpreet Kaur, Jay Malaguit, Devin William McBride, Jiping Tang, John H. Zhang
Format: Article
Language:English
Published: The Company of Biologists 2019-11-01
Series:Disease Models & Mechanisms
Subjects:
neonatal hypoxia ischemia
bax inhibitor 1
tmbim6
er stress
apoptosis
Online Access:http://dmm.biologists.org/content/12/11/dmm040352

Internet

http://dmm.biologists.org/content/12/11/dmm040352

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