Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells

Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells

Abstract Background The bcr-abl fusion gene encodes BCR-ABL oncoprotein and plays a crucial role in the leukemogenesis of chronic myeloid leukemia (CML). Current therapeutic methods have limited treatment effect on CML patients with drug resistance or disease relapse. Therefore, novel therapeutic st...

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Bibliographic Details
Main Authors: Zhenhong Luo, Miao Gao, Ningshu Huang, Xin Wang, Zesong Yang, Hao Yang, Zhenglan Huang, Wenli Feng
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Chronic myeloid leukemia
RNA guided-FokI nucleases
Bcr-abl
Homology-directed repair
Leukemogenesis
Online Access:http://link.springer.com/article/10.1186/s13046-019-1229-5

Internet

http://link.springer.com/article/10.1186/s13046-019-1229-5

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