EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7...

Full description

Bibliographic Details
Main Authors: Florian Wanke, Sonja Moos, Andrew L. Croxford, André P. Heinen, Stephanie Gräf, Bettina Kalt, Denise Tischner, Juan Zhang, Isabelle Christen, Julia Bruttger, Nir Yogev, Yilang Tang, Morad Zayoud, Nicole Israel, Khalad Karram, Sonja Reißig, Sonja M. Lacher, Christian Reichhold, Ilgiz A. Mufazalov, Avraham Ben-Nun, Tanja Kuhlmann, Nina Wettschureck, Andreas W. Sailer, Klaus Rajewsky, Stefano Casola, Ari Waisman, Florian C. Kurschus
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
EBI2
GPR183
7α,25-OHC
oxysterol
CH25H
Th17
EAE
CNS
multiple sclerosis
microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300578

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717300578

Similar Items