Efficiently activated ε‐poly‐L‐lysine production by multiple antibiotic‐resistance mutations and acidic pH shock optimization in Streptomyces albulus

Efficiently activated ε‐poly‐L‐lysine production by multiple antibiotic‐resistance mutations and acidic pH shock optimization in Streptomyces albulus

Abstract ε‐Poly‐L‐lysine (ε‐PL) is a food additive produced by Streptomyces and is widely used in many countries. Working with Streptomyces albulus FEEL‐1, we established a method to activate ε‐PL synthesis by successive introduction of multiple antibiotic‐resistance mutations. Sextuple mutant R6 wa...

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Bibliographic Details
Main Authors: Liang Wang, Shu Li, Junjie Zhao, Yongjuan Liu, Xusheng Chen, Lei Tang, Zhonggui Mao
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:MicrobiologyOpen
Subjects:
ε‐PL overproduction
acid pH shock optimization
high production analysis
multiple antibiotic‐resistance mutations
ribosome engineering
Streptomyces
Online Access:https://doi.org/10.1002/mbo3.728

Internet

https://doi.org/10.1002/mbo3.728

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