Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response

Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response

Airway smooth muscle constriction induced by cholinergic agonists such as methacholine (MCh), which is typically increased in asthmatic patients, is regulated mainly by muscle muscarinic M3 receptors and negatively by vagal muscarinic M2 receptors. Here we evaluated basal (intrinsic) and allergen-in...

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Main Authors: Juciane Maria de Andrade Castro, Rodrigo R. Resende, Luciana Mirotti, Esther Florsheim, Layra Lucy Albuquerque, Adriana Lino-dos-Santos-Franco, Eliane Gomes, Wothan Tavares de Lima, Marcelo de Franco, Orlando Garcia Ribeiro, Momtchilo Russo
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/805627

Internet

http://dx.doi.org/10.1155/2013/805627

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