Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases

Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases

Neurons are extremely energy demanding cells and highly dependent on the mitochondrial oxidative phosphorylation (OXPHOS) system. Mitochondria generate the energetic potential via the respiratory complexes I to IV, which constitute the electron transport chain (ETC), together with complex V. These r...

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Bibliographic Details
Main Authors: Gabriele Giachin, Romain Bouverot, Samira Acajjaoui, Serena Pantalone, Montserrat Soler-Lopez
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
Parkinson’s disease
neurodegeneration
Alzheimer’s disease
Complex I
Mitochondrial dysfunction
assembly factors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00043/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2016.00043/full

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