Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

The spindle assembly checkpoint ensures correct chromosome segregation and relies on kinetochore localization of the Bub1 and Mad1/Mad2 checkpoint proteins. Here the authors show that main function of Bub1 is to position Mad1 close to KNL1 MELT repeats in human cells.

Bibliographic Details
Main Authors: Gang Zhang, Thomas Kruse, Blanca López-Méndez, Kathrine Beck Sylvestersen, Dimitriya H. Garvanska, Simone Schopper, Michael Lund Nielsen, Jakob Nilsson
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15822

Internet

https://doi.org/10.1038/ncomms15822

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