APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model

APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model

Summary: Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer’s disease (AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived from APP are pathogenic, the APP holoprotein serves multiple purposes in the nervous system through its cell adhesion and receptor-li...

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Bibliographic Details
Main Authors: Carole Deyts, Mary Clutter, Nicholas Pierce, Paramita Chakrabarty, Thomas B. Ladd, Anna Goddi, Awilda M. Rosario, Pedro Cruz, Kulandaivelu Vetrivel, Steven L. Wagner, Gopal Thinakaran, Todd E. Golde, Angèle T. Parent
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719304267

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http://www.sciencedirect.com/science/article/pii/S2211124719304267

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