Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain

Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain

CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders are thought to mediate T cell entry into the parenchyma during neuroinflammation. The identity of the CNS-resident A...

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Bibliographic Details
Main Authors: Emma N. Goddery, Cori E. Fain, Chloe G. Lipovsky, Katayoun Ayasoufi, Lila T. Yokanovich, Courtney S. Malo, Roman H. Khadka, Zachariah P. Tritz, Fang Jin, Michael J. Hansen, Aaron J. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
microglia
antigen presentation
TMEV
viral infection
MHC class I
perivascular macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.726421/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.726421/full

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