Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation

Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation

Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated by knockout mice lacking GluA1. In GluA1 knock...

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Bibliographic Details
Main Authors: Derya R. Shimshek, Thorsten Bus, Bettina Schupp, Vidar Jensen, Verena Marx, Liliana E. Layer, Georg Köhr, Rolf Sprengel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
AMPA receptors
GluA1
GluA2
Gria1 knockout mice
Gria2 knockout mice
long-term potentiation (LTP)
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00214/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00214/full

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