Mechanisms of Spontaneous Climbing Fiber Discharge-Evoked Pauses and Output Modulation of Cerebellar Purkinje Cell in Mice

Mechanisms of Spontaneous Climbing Fiber Discharge-Evoked Pauses and Output Modulation of Cerebellar Purkinje Cell in Mice

Climbing fiber (CF) afferents modulate the frequency and patterns of cerebellar Purkinje cell (PC) simple spike (SS) activity, but its mechanism is unclear. In the present study, we investigated the mechanisms of spontaneous CF discharge-evoked pauses and the output modulation of cerebellar PCs in u...

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Bibliographic Details
Main Authors: Xian-Hua Jin, Hong-Wei Wang, Xin-Yuan Zhang, Chun-Ping Chu, Yuan-Zhe Jin, Song-Biao Cui, De-Lai Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cerebellar Purkinje cell
whole-cell patch-clamp recording
complex spike (CS)
after-hyperpolarization (AHP)
simple-spike (SS)
small conductance calcium-activated potassium channel (SK)
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00247/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00247/full

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