A point mutation in a herpesvirus polymerase determines neuropathogenicity.

A point mutation in a herpesvirus polymerase determines neuropathogenicity.

Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the EHV-1 DNA polymerase (N752/D752) is significa...

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Bibliographic Details
Main Authors: Laura B Goodman, Arianna Loregian, Gillian A Perkins, Josie Nugent, Elizabeth L Buckles, Beatrice Mercorelli, Julia H Kydd, Giorgio Palù, Ken C Smith, Nikolaus Osterrieder, Nicholas Davis-Poynter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2065875?pdf=render

Internet

http://europepmc.org/articles/PMC2065875?pdf=render

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