A point mutation in a herpesvirus polymerase determines neuropathogenicity.
Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an amino acid variation of the EHV-1 DNA polymerase (N752/D752) is significa...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-11-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2065875?pdf=render |