Expression of the EGF family in gastric cancer: downregulation of HER4 and its activating ligand NRG4.

Gastric cancer is a major cause of cancer-related deaths in both men and women. The epidermal growth factor receptors are EGFR, HER2, HER3 and HER4. Of the four epidermal growth factor receptors, EGFR and HER2 are well-known oncogenes involved in gastric cancer. Little, however, is known about the r...

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Bibliographic Details
Main Authors: Trine Ostergaard Nielsen, Lennart Friis-Hansen, Steen Seier Poulsen, Birgitte Federspiel, Boe Sandahl Sorensen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3984243?pdf=render