Preparation and Optimization of In Situ Gel Loaded with Rosuvastatin-Ellagic Acid Nanotransfersomes to Enhance the Anti-Proliferative Activity

Preparation and Optimization of In Situ Gel Loaded with Rosuvastatin-Ellagic Acid Nanotransfersomes to Enhance the Anti-Proliferative Activity

The objective of this study was to develop an optimized sustained-release nanotransfersomes (NTS) based in situ gel formulation of rosuvastatin (RO) combined with ellagic acid (EA) antioxidant, to enhance cytotoxic and anti-proliferative activity against tongue carcinoma. The concentrations of lecit...

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Bibliographic Details
Main Authors: Khaled M. Hosny, Waleed Y. Rizg, Rasha A. Khallaf
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
rosuvastatin
antioxidant
ellagic acid
box behnken design
nanotransferosomes
in situ gel
human chondrosarcome-3 cell line
tongue carcinoma
Online Access:https://www.mdpi.com/1999-4923/12/3/263

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https://www.mdpi.com/1999-4923/12/3/263

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