Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels.

Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels.

OBJECTIVE: Pigment epithelium-derived factor (PEDF) belongs to the serpin family of peptidase inhibitors (serpin F1) and is among the most abundant glycoproteins secreted by adipocytes. In vitro and mouse in vivo data revealed PEDF as a candidate mediator of obesity-induced insulin resistance. There...

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Bibliographic Details
Main Authors: Anja Böhm, Anna-Maria Ordelheide, Jürgen Machann, Martin Heni, Caroline Ketterer, Fausto Machicao, Fritz Schick, Norbert Stefan, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3311576?pdf=render

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http://europepmc.org/articles/PMC3311576?pdf=render

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