Collective forces of tumor spheroids in three-dimensional biopolymer networks

Collective forces of tumor spheroids in three-dimensional biopolymer networks

We describe a method for quantifying the contractile forces that tumor spheroids collectively exert on highly nonlinear three-dimensional collagen networks. While three-dimensional traction force microscopy for single cells in a nonlinear matrix is computationally complex due to the variable cell sh...

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Bibliographic Details
Main Authors: Christoph Mark, Thomas J Grundy, Pamela L Strissel, David Böhringer, Nadine Grummel, Richard Gerum, Julian Steinwachs, Carolin C Hack, Matthias W Beckmann, Markus Eckstein, Reiner Strick, Geraldine M O'Neill, Ben Fabry
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
traction force microscopy
tumor spheroids
multicellular aggregates
biopolymer gels
tumoroids
collective force generation
Online Access:https://elifesciences.org/articles/51912

Internet

https://elifesciences.org/articles/51912

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