Quantitative epistasis analysis and pathway inference from genetic interaction data.
Inferring regulatory and metabolic network models from quantitative genetic interaction data remains a major challenge in systems biology. Here, we present a novel quantitative model for interpreting epistasis within pathways responding to an external signal. The model provides the basis of an exper...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-05-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC3093353?pdf=render |