Quantitative epistasis analysis and pathway inference from genetic interaction data.

Quantitative epistasis analysis and pathway inference from genetic interaction data.

Inferring regulatory and metabolic network models from quantitative genetic interaction data remains a major challenge in systems biology. Here, we present a novel quantitative model for interpreting epistasis within pathways responding to an external signal. The model provides the basis of an exper...

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Bibliographic Details
Main Authors: Hilary Phenix, Katy Morin, Cory Batenchuk, Jacob Parker, Vida Abedi, Liu Yang, Lioudmila Tepliakova, Theodore J Perkins, Mads Kærn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3093353?pdf=render

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http://europepmc.org/articles/PMC3093353?pdf=render

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