Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion

Neutrophil elastase (NE) degrades basal lamina and extracellular matrix molecules, and recruits leukocytes during inflammation; however, a basic understanding of the role of NE in stroke pathology is lacking. We measured an increased number of extravascular NE-positive cells, as well as increased le...

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Bibliographic Details
Main Authors: Ann M. Stowe, Tracy L. Adair-Kirk, Ernesto R. Gonzales, Ronald S. Perez, Aarti R. Shah, Tae S. Park, Jeffrey M. Gidday
Format: Article
Language:English
Published: Elsevier 2009-07-01
Series:Neurobiology of Disease
Subjects:
Protease
Blood–brain barrier
Ischemia
Transient middle cerebral artery occlusion
Vasogenic edema
Leukocyte–endothelial adherence
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000837

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http://www.sciencedirect.com/science/article/pii/S0969996109000837

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