In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy

In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy

The therapeutic efficiency of active targeting nanoparticulate drug delivery systems (nano-DDS) is highly compromised by the plasma proteins adsorption on nanoparticles (NPs) surface, which significantly hinders cell membrane receptors to recognize the designed ligands, and provokes the off-target t...

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Bibliographic Details
Main Authors: Zhenbao Li, Jiaojiao Zhu, Yongqi Wang, Mei Zhou, Dan Li, Shunzhe Zheng, LiLi Yin, Cong Luo, Huicong Zhang, Lu Zhong, Wei Li, Jian Wang, Shuangying Gui, Biao Cai, Yongjun Wang, Jin Sun
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
In situ ApoE-enriched corona
DHA decoration
Nanoparticulate drug delivery system
LDLr-mediated tumor-homing chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087619301515

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http://www.sciencedirect.com/science/article/pii/S1818087619301515

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