Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.

Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.

OBJECTIVE: Most gain of function mutations of tyrosine kinase receptors in human tumours are hemizygous. Gastrointestinal stromal tumours (GIST) with homozygous mutations have a worse prognosis. We aimed to identify genes differentially regulated by hemizygous and heterozygous KIT mutations. MATERIA...

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Bibliographic Details
Main Authors: Jean-Baptiste Bachet, Séverine Tabone-Eglinger, Sophie Dessaux, Anthony Besse, Sabrina Brahimi-Adouane, Jean-François Emile, Jean-Yves Blay, Laurent Alberti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3625162?pdf=render

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http://europepmc.org/articles/PMC3625162?pdf=render

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