Mechanistic Pathways for Peptidoglycan O-Acetylation and De-O-Acetylation

Mechanistic Pathways for Peptidoglycan O-Acetylation and De-O-Acetylation

The post-synthetic O-acetylation of the essential component of bacterial cell walls, peptidoglycan (PG), is performed by many pathogenic bacteria to help them evade the lytic action of innate immunity responses. Occurring at the C-6 hydroxyl of N-acetylmuramoyl residues, this modification to the gly...

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Bibliographic Details
Main Authors: David Sychantha, Ashley S. Brott, Carys S. Jones, Anthony J. Clarke
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Microbiology
Subjects:
peptidoglycan
O-acetylation
O-acetyltransferase
O-acetylesterase
SGNH hydrolase
catalytic mechanism
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02332/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02332/full

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