The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

In this study, laser-induced in situ amorphization (i.e., amorphization inside the final dosage form) of the model drug celecoxib (CCX) with six different polymers was investigated. The drug–polymer combinations were studied with regard to the influence of (i) the physicochemical properties of the p...

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Bibliographic Details
Main Authors: Nele-Johanna Hempel, Padryk Merkl, Matthias Manne Knopp, Ragna Berthelsen, Alexandra Teleki, Georgios A. Sotiriou, Korbinian Löbmann
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
oral drug delivery
in situ drug amorphization
polymers
amorphous solid dispersion
laser radiation
plasmonic nanoparticles
Online Access:https://www.mdpi.com/1999-4923/13/6/917

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https://www.mdpi.com/1999-4923/13/6/917

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