A computational model of feedback-mediated hematopoietic stem cell differentiation in vitro.

Hematopoietic stem cells (HSCs) play an important physiological role as regulators of all blood and immune cell populations, and are of clinical importance for bone marrow transplants. Regulating HSC biology in vitro for clinical applications requires improved understanding of biological inducers of...

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Bibliographic Details
Main Authors: Bhushan Mahadik, Bruce Hannon, Brendan A C Harley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212502