Evidence for a peak shift in a humoral response to helminths: age profiles of IgE in the Shuar of Ecuador, the Tsimane of Bolivia, and the U.S. NHANES.

Evidence for a peak shift in a humoral response to helminths: age profiles of IgE in the Shuar of Ecuador, the Tsimane of Bolivia, and the U.S. NHANES.

The peak shift model predicts that the age-profile of a pathogen's prevalence depends upon its transmission rate, peaking earlier in populations with higher transmission and declining as partial immunity is acquired. Helminth infections are associated with increased immunoglobulin E (IgE), whic...

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Bibliographic Details
Main Authors: Aaron D Blackwell, Michael D Gurven, Lawrence S Sugiyama, Felicia C Madimenos, Melissa A Liebert, Melanie A Martin, Hillard S Kaplan, J Josh Snodgrass
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3125146?pdf=render

Internet

http://europepmc.org/articles/PMC3125146?pdf=render

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